Assuming you do have other backups, and it's not a system drive, I would start with a fixmbr, then a full format. Then if it's still doing it and there's nothing reported, such as bad clusters, I would suspect the source of the data which would be the software if it's localised, or perhaps a bad drive controller if said drive is on its own on that controller. In fact, it could be any number of hardware issues, but you should see patterns, and if they're specific to the drive (but not the controller) it's most likely the MBR or a software issue on the drive (virus / bad driver / no idea!
© Camieabz 2002-2012
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Scottish Labour politician: “The SNP are on a very dangerous tack. What they are doing is trying to build up a situation in Scotland where the services are manifestly better than south of the border in a number of areas.”
Interviewer: ”Is that a bad thing?”
Scottish Labour politician: “No, but they are doing it deliberately.”