I use 2 QNAP 410s each with 4 2tb drives
They have provided perfect service for a couple of years now, I must admit I have not delved into the more advanced features like webservers etc but for what I do (Movie & TV Storage), played back across a wired network they have been perfect,
Don't think you will have any reliability issues if you go for QNAP
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We are in the process of buying a network attached storage for our backups at work and currently looking at this one QNap TS-459 Pro+.
An one has any comments about it good or bad? are there better ones?