After completing RE4, I decided to play this again (been a long time). The original (disk based) version isn't compatible with Windows 10 (due to Game for Windows, so the modified Steam version is needed). However, that too does have problems - on one computer the game kept hanging on the part where you get the crowd hitting a sack, whilst another computer has crashes in the system menu (when changing settings).
Whether it works seems to be down to luck really - so you need to be wary about getting it. It is generally fine if you dont change any settings