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I am sitting here, typing this message on a machine running 64 bit.
Before Windows 7 I would've said, don't bother, XP and Vista really didn't bother too much with x64 so neither did the development community. The same can be said of Linux distros until recently.
I've always thought that luddism to be just a bit of a non sequitur - it's the modern day equivalent of replacing Windows 98/2000 with Windows 3.1 on the basis that you have a few 16 bit Windows applications.
I've benchmarked Windows 2003 x64 compared to its x86 brother, and while x86 did boot faster to the desktop, x64 was way more stable (and performed better overall) when IIS, Sharepoint and SQL were all running on the same box with the same amount of RAM.
Vista (even the x86 variety) failed my compatibility testing for some applications, but it is a reasonable performer in its x64 incarnation for 99% of the stuff I have to do, and I can run a VM to do everything else. So, I'm running Vista x64 on my work machine. Vista x86 was marginally faster when not actually having to do very much, but as soon as I put it under load, it had a tendency to get sluggish - the x64 version (on the exact same machine with the same apps loaded) doesn't experience that issue.
Windows 7 in both flavours trounces Vista for application compatibility and performance but again x64 does appear to cope with heavy workloads a lot better than x86.
Anecdotally, I know of a reasonable sized company (over 500 staff in over a dozen offices across the UK) who were already edging toward selecting Windows 7 for rollout to all their desktops, all the way back in June.
They found x86 was marginally faster for boot-up and "bog standard" apps like Office and Internet Explorer but as soon as they whacked something more intensive on the machine, like Visual Studio or video authoring applications, x64 just seemed to cope better.
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